Halotestin
Fluoxymesterone · Halo
Extremely hepatotoxic oral; pure strength/aggression, minimal hypertrophy.
Key takeaways
- Fluorinated oral DHT derivative; approved for hypogonadism, known for strength without mass.
- ~2-hour half-life; split dosing twice daily to avoid deep troughs.
- Does not aromatize; side effects are androgenic, not estrogenic.
- Most hepatotoxic oral in the dataset; runs stay short and liver enzymes need watching.
Overview
What it is
Halotestin (fluoxymesterone) is an oral fluorinated DHT derivative, FDA-approved for male hypogonadism and historically used in advanced breast cancer. The 9-alpha-fluoro group blocks aromatization entirely and tilts its effect toward raw androgenic action: strength and aggression, with little mass for the potency.
Pharmacokinetics
The ~2-hour half-life produces fast peaks and troughs, so documented dosing splits twice daily. Bioavailability sits around 57% after first-pass loss, with a peak roughly 1–2 hours post-dose.
Harm reduction
This is the most hepatotoxic oral in the dataset; lipids and blood pressure also move fast. Reported runs stay short (2–4 weeks is the community norm), and liver enzyme monitoring is the core safeguard. Androgenic sides (hair, skin, aggression) are pronounced.
Reported dosing protocols
Protocols reported in research literature and clinic/community use — informational context, not a dosing recommendation.
| Use case | Dose | Route | Frequency | Duration |
|---|---|---|---|---|
| Hypogonadism (label) | 5–20 mg daily | Oral | 1–2× daily | Ongoing (monitored) |
| Strength peaking (community) | 10–30 mg daily | Oral | 2× daily | 2–4 weeks |
Pharmacokinetic summary
- Model tier
- Advanced (t½ + Cmax + Tmax + F)
- Half-life
- 2.0 hours
- Cmax
- 800 ng/dL
- Tmax
- 0.1 days
- Bioavailability
- 57%
- Typical dose
- 5–30 mg
Harm reduction
- Aromatizes
- No
- DHT derivative
- Yes
- Hepatotoxicity
- severe
- Injection frequency
- Oral, 2×/day
Frequently asked questions
What is Halotestin actually used for?
Clinically it was prescribed for male hypogonadism and palliative breast-cancer treatment, though safer options have replaced it. In strength sports it's reported as a peaking drug: noticeable strength and aggression gains without the water weight that matters in a weight class.
Why doesn't Halotestin build much muscle?
Its anabolic activity is modest relative to its androgenic potency; most of the felt effect is aggression and neural drive rather than new tissue. The numbers users report (real strength gain, minimal scale weight) match that pharmacology.
How long do reported Halotestin runs last?
Typically 2–4 weeks, because hepatotoxicity and lipid disruption accumulate quickly. The ~2-hour half-life means it clears within a day or two of stopping, which is why it's used right up to competitions.
References
- PubMed (fluoxymesterone) — Estimated first-pass loss 43%.
- Fluoxymesterone clinical pharmacology (PubMed) — Primary human PK reference behind the half-life and bioavailability figures.
Related compounds
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