CJC-1295 without DAC (Modified GRF 1-29)
Mod GRF 1-29 · CJC-1295 NO DAC · CJC no DAC
Short-acting GHRH analog (~30 min half-life) usually paired with a GHRP for pulsatile GH release.
Key takeaways
- Short-acting GHRH analog (Mod GRF 1-29) with a ~30-minute half-life.
- Produces physiologic GH pulses rather than the DAC version's sustained elevation.
- Usually stacked 1:1 with a GHRP (ipamorelin, GHRP-2) for a larger pulse.
- Direct human trials are lacking; dosing conventions are community-derived.
Overview
What it is
CJC-1295 without DAC, better known as modified GRF 1-29, is a short-acting GHRH analog with four amino acid substitutions that resist enzymatic breakdown. It acts on pituitary GHRH receptors to trigger growth hormone release in a pulsatile, physiologic pattern.
Pharmacokinetics
Without the albumin-binding DAC, the half-life drops back to roughly 30 minutes with around 60% subcutaneous bioavailability. That short window is why it is almost always paired with a GHRP like ipamorelin: the two classes amplify GH release through separate receptors.
What the evidence says
Direct human data on this modified analog is thin. The parent GRF(1-29) sequence (sermorelin) has real clinical history, but the modified peptide's dosing conventions are community-derived, and it is not an approved medication.
Reported dosing protocols
Protocols reported in research literature and clinic/community use — informational context, not a dosing recommendation.
| Use case | Dose | Route | Frequency | Duration |
|---|---|---|---|---|
| GH pulse (community) | 100–300 mcg | SubQ | 1–3× daily, fasted or pre-bed | 8–12 weeks |
Pharmacokinetic summary
- Model tier
- Simple (t½ + F, Tmax estimated)
- Half-life
- 29 min
- Bioavailability
- 60%
- Typical dose
- 0.1–0.5 mg
Frequently asked questions
Why combine CJC-1295 no DAC with a GHRP?
GHRH analogs and GHRPs hit different receptors (GHRH-R vs the ghrelin receptor), and the combination is synergistic: the GH pulse from both together exceeds either alone. That is why blends like CJC/ipamorelin are standard in research use.
Why dose it fasted or before bed?
Food and elevated blood sugar blunt GH release, so fasted dosing gives a cleaner pulse. Pre-bed dosing aims to amplify the large natural nocturnal GH pulse. The logic is physiological, though comparative human data is lacking.
Mod GRF vs CJC-1295 with DAC — how do they differ?
Same base peptide, different duration. Without DAC the half-life is ~30 minutes and dosing is daily, often multiple times. With DAC, one injection gives about a week of sustained elevation. Vendor labeling mix-ups between the two are a known community complaint.
References
- Estimated — Without DAC the half-life is ~30 minutes; typically combined with a GHRP.
Related compounds
CJC-1295 with DAC
Long-acting GHRH analog with a drug-affinity complex that extends half-life to ~6–8 days; weekly dosing.
Sermorelin
Bioidentical GHRH fragment used diagnostically and off-label to stimulate endogenous growth hormone.
Tesamorelin
N-terminally stabilized GHRH analog approved to reduce excess visceral fat in HIV lipodystrophy.
Protocols featuring CJC-1295 without DAC (Modified GRF 1-29)
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