Kisspeptin
Kisspeptin-10 · Metastin
Neuropeptide that drives GnRH release upstream of the HPG axis; researched for hormone restoration.
Key takeaways
- Upstream regulator of GnRH neurons via the KISS1R (GPR54) receptor.
- Half-life is about 30 minutes; human studies used IV kisspeptin-54 or kisspeptin-10.
- Human data shows LH/FSH stimulation, but no therapeutic trial or approval exists.
- Recovery and fertility claims are extrapolation from physiology studies, not outcomes data.
Reported dosing protocols
Protocols reported in research literature and clinic/community use — informational context, not a dosing recommendation.
| Use case | Dose | Route | Frequency | Duration |
|---|---|---|---|---|
| HPG-axis research (published studies) | Low nmol/kg boluses | IV | Single bolus or infusion | Study session |
| Hormone-axis support (community) | 250–1,000 mcg | SubQ | 1–2× daily | 2–4 weeks |
Pharmacokinetic summary
- Model tier
- Simple (t½ + F, Tmax estimated)
- Half-life
- 29 min
- Bioavailability
- 40%
- Typical dose
- 0.25–1 mg
Frequently asked questions
How is kisspeptin different from gonadorelin?
Both target the reproductive axis, but at different levels. Gonadorelin is GnRH itself, acting directly on the pituitary. Kisspeptin acts one step earlier, switching GnRH neurons on via the KISS1R receptor, which preserves more of the natural signaling pattern.
Can kisspeptin restore hormones after suppression?
That's the research rationale, and human studies confirm it stimulates LH release even in some suppressed states. What's missing is outcome data: no trial has shown it restores fertility or speeds recovery from anabolic-steroid suppression.
Is kisspeptin approved?
No. It has no approved indication anywhere. Human exposure data comes from academic physiology studies, which consistently show it's well tolerated at research doses, but that's not the same as a safety-approval process.
References
- Estimated — Upstream regulator of GnRH neurons; short half-life (~minutes).
- Dhillo et al., JCEM 2005 — kisspeptin-54 stimulates the HPG axis in human males — First-in-human demonstration that kisspeptin-54 potently raises LH, FSH, and testosterone.
Related compounds
HCG
Human chorionic gonadotropin; mimics LH, used on-cycle and in PCT to preserve testicular function.
HMG (Menotropin)
Human menopausal gonadotropin providing FSH and LH activity; used in PCT and fertility protocols.
Gonadorelin Acetate
Native gonadotropin-releasing hormone; stimulates LH/FSH release. Pulsatile (not continuous) use matters.
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