Beginner Testosterone Enanthate (12 weeks)
The canonical first cycle: 500 mg Test E per week (250 mg 2×/week) for 12 weeks. The most-cited textbook beginner cycle.
Concentration over time
Model details: Testosterone Enanthate
How to read this chart
This is a study-based example of how testosterone levels change over time. Try different doses or timing to compare the curves.
The calculation uses the same assumptions for everyone. It can't predict your own blood levels or tell you what dose to take.
Only testosterone from the entered doses is shown. Your body's own production isn't included, so this isn't your total blood level.
Study setup and sources
testosterone: exogenous contribution in serum (ng/dL).
The body's own testosterone is excluded. This is the contribution from entered doses, not the total blood level.
Fixed reference profile: Ten adult men with hypogonadism already receiving IM testosterone enanthate; adult model reanalysis of the 2015 cohort. Testosterone enanthate 200 mg/mL in sesame oil (West-Ward), as studied in the IM reference cohort.; Intramuscular. Fixed reference weight: 90.35 kg.
Changing dose or schedule explores a scenario; it does not personalize the reference profile or establish a studied regimen.
Input dose basis: Nominal testosterone enanthate mg
Source exposure scope: The adult IM source cohort received a 200 mg study injection on existing treatment. Other schedules are simulations under fixed linear parameters, not additional observed regimens.
Adult IM testosterone enanthate: injected-drug model component
vogiatzi-2023-enanthate-im-component · version 1
- Published adult fixed-effect parameters; no individual random effects or pediatric allometric scaling.
- Zero initial exogenous amount and no endogenous testosterone contribution. Prior treatment is included only when its dose events are entered.
- Nominal testosterone enanthate dose enters the model directly; no additional ester-mass or bioavailability multiplier.
- Model structure
- One compartment with absorption
- Apparent clearance (CL/F)
- 50.569 L/hour
- Apparent central volume (Vc/F)
- 13755.8 L
- Absorption rate (ka)
- 0.0831 /hour
- Input mass conversion
- 1 mg modelled mass per mg entered
- This mathematical injected-drug component is not a measured fraction of an individual blood sample or a prediction of total testosterone.
- The small source cohort had prior treatment and variable endogenous testosterone. Clinical effects, endogenous recovery and fertility are not modeled.
- These IM parameters do not describe subcutaneous autoinjectors, other formulations or pediatric patients.
- Changing a simulated dose or interval does not establish treatment suitability, a testing date or an expected change in adverse effects.
- Vogiatzi et al. 2023 — adult IM population model
Adult one-compartment model; pediatric simulations in the paper are not implemented.
- Vogiatzi et al. — supplementary Table 3 and Figures 7–8
Full-precision IM fixed effects: Ka 0.0831/h, V 13755.8 L, CL 50.569 L/h. Figure 8 includes different initial endogenous levels, excluded from this component.
- Kaminetsky et al. 2015 — underlying clinical cohort
The IM sesame-oil reference arm is separate from the subcutaneous autoinjector arms; observed total-testosterone endpoints are not isolated-dose peaks.
| Date | Testosterone Enanthate · Testosterone from entered doses only (ng/dL) |
|---|---|
| W1 | 0 ng/dL |
| W2 | 2848.54 ng/dL |
| W3 | 4476.86 ng/dL |
| W3 | 5349.18 ng/dL |
| W4 | 5685.96 ng/dL |
| W5 | 5687.76 ng/dL |
| W6 | 5208.46 ng/dL |
| W7 | 5521.74 ng/dL |
| W8 | 5797.8 ng/dL |
| W9 | 5977.75 ng/dL |
| W10 | 6042.82 ng/dL |
| W11 | 6164.63 ng/dL |
| W12 | 6159.88 ng/dL |
The chart uses a bounded time grid. Long horizons can miss brief peaks between samples; shorten the horizon to inspect more detail. Chart peaks are sampled values.
Protocol summary
Beginner Testosterone Enanthate (12 weeks) · 12 weeks starting Oct 30, 26
- Testosterone Enanthate — 250.0 mg 2×/week (Mon/Thu), weeks 0–12
Protocol overview
- Category
- aas cycle
- Duration
- 12 weeks
- Compounds
- 1
- Tags
- beginner, testosterone, 12-week
Compounds in this protocol
- Testosterone Enanthate — 250 mg, 2x-per-week
How to read this protocol
The chart shows available model curves over the 12-week example. Rows whose model is unavailable are retained for context but produce no curve. Read each model’s details for what its line represents; a plotted level does not predict treatment effects or establish a suitable dose.
The peak/trough explorer examines one complete model interval. The single-dose decline explorer is a separate one-dose scenario; it does not calculate this protocol's washout or a safe treatment-change date. Read the recovery reference for PCT evidence and its limits.
Educational only. Not medical advice. These examples do not predict individual blood levels.