Testosterone Model Explorer
Explore available model assumptions and mathematical frequency comparisons; these outputs do not predict your bloodwork.
Compare model outputs under two mathematical schedules; this does not recommend an injection frequency.
Model details: Testosterone Enanthate
How to read this chart
This is a study-based example of how testosterone levels change over time. Try different doses or timing to compare the curves.
The calculation uses the same assumptions for everyone. It can't predict your own blood levels or tell you what dose to take.
Only testosterone from the entered doses is shown. Your body's own production isn't included, so this isn't your total blood level.
Study setup and sources
testosterone: exogenous contribution in serum (ng/dL).
The body's own testosterone is excluded. This is the contribution from entered doses, not the total blood level.
Fixed reference profile: Ten adult men with hypogonadism already receiving IM testosterone enanthate; adult model reanalysis of the 2015 cohort. Testosterone enanthate 200 mg/mL in sesame oil (West-Ward), as studied in the IM reference cohort.; Intramuscular. Fixed reference weight: 90.35 kg.
Changing dose or schedule explores a scenario; it does not personalize the reference profile or establish a studied regimen.
Input dose basis: Nominal testosterone enanthate mg
Source exposure scope: The adult IM source cohort received a 200 mg study injection on existing treatment. Other schedules are simulations under fixed linear parameters, not additional observed regimens.
Adult IM testosterone enanthate: injected-drug model component
vogiatzi-2023-enanthate-im-component · version 1
- Published adult fixed-effect parameters; no individual random effects or pediatric allometric scaling.
- Zero initial exogenous amount and no endogenous testosterone contribution. Prior treatment is included only when its dose events are entered.
- Nominal testosterone enanthate dose enters the model directly; no additional ester-mass or bioavailability multiplier.
- Model structure
- One compartment with absorption
- Apparent clearance (CL/F)
- 50.569 L/hour
- Apparent central volume (Vc/F)
- 13755.8 L
- Absorption rate (ka)
- 0.0831 /hour
- Input mass conversion
- 1 mg modelled mass per mg entered
- This mathematical injected-drug component is not a measured fraction of an individual blood sample or a prediction of total testosterone.
- The small source cohort had prior treatment and variable endogenous testosterone. Clinical effects, endogenous recovery and fertility are not modeled.
- These IM parameters do not describe subcutaneous autoinjectors, other formulations or pediatric patients.
- Changing a simulated dose or interval does not establish treatment suitability, a testing date or an expected change in adverse effects.
- Vogiatzi et al. 2023 — adult IM population model
Adult one-compartment model; pediatric simulations in the paper are not implemented.
- Vogiatzi et al. — supplementary Table 3 and Figures 7–8
Full-precision IM fixed effects: Ka 0.0831/h, V 13755.8 L, CL 50.569 L/h. Figure 8 includes different initial endogenous levels, excluded from this component.
- Kaminetsky et al. 2015 — underlying clinical cohort
The IM sesame-oil reference arm is separate from the subcutaneous autoinjector arms; observed total-testosterone endpoints are not isolated-dose peaks.
Modeled estimate — not a prediction.
A selectable entry does not establish that its curve predicts measured total testosterone. Source, formulation and calibration limitations still apply. Product-specific bloodwork timing and dosing decisions need clinical interpretation.
Model outputs for the selected interval
Testosterone from entered doses only
Highest sampled model level
Lowest sampled model level
Sample mean over interval
These are sampled model outputs, not measured blood levels or exact continuous extrema. The summary uses the last full injection interval of a 12-week input (13 modeled dose events); this sampling choice does not establish clinical steady state.
Modeled concentration curve
| Date | ng/dL |
|---|---|
| Oct 30 | 0.000 ng/dL |
| Nov 6 | 820 ng/dL |
| Nov 13 | 1.26k ng/dL |
| Nov 20 | 1.50k ng/dL |
| Nov 27 | 1.63k ng/dL |
| Dec 4 | 1.70k ng/dL |
| Dec 11 | 1.74k ng/dL |
| Dec 18 | 1.76k ng/dL |
| Dec 25 | 1.77k ng/dL |
| Jan 1 | 1.77k ng/dL |
| Jan 8 | 1.78k ng/dL |
| Jan 15 | 1.78k ng/dL |
| Jan 22 | 1.78k ng/dL |
No clinical reference band or normal-range classification is applied to this unvalidated model output.
Educational use only — not medical advice. This is a modeled estimate from a linear pharmacokinetic model with the selected reference assumptions, not a prediction of your bloodwork. Individual clearance, ester purity, injection technique, body composition, SHBG, and assay variability all shift real levels — sometimes substantially. Never start, stop, or adjust TRT based on this tool; use product-specific clinical advice and interpreted bloodwork.
About this tool
Compare calculated concentration patterns under two model schedules. The cypionate and enanthate reference models show the injected-drug contribution with fixed source parameters; they exclude endogenous testosterone production and do not predict your total blood testosterone or identify a suitable treatment dose. Read the selected model’s scope and limitations.
How to use it
- 1 Read the selected model’s output definition, formulation, reference population and source. Different esters and study populations are not interchangeable calibrations.
- 2 For an available entry, choose model inputs and a horizon. Defaults are examples, not a prescribed regimen.
- 3 Compare the calculated values with the assumptions and source notes attached to that entry. The horizon alone does not establish steady state.
- 4 Use the appropriate product information and clinical assessment for treatment or monitoring decisions; this model does not set either.
Frequently asked questions
Can these values predict my testosterone blood test?
No. A stored concentration scale, a dose-response assumption and a plotted curve do not establish an individual total-testosterone result. Formulation, population, endogenous hormone production and the measurement endpoint must match before clinical interpretation is possible.
What changed in the cypionate and enanthate models?
The old display-tuned peak scales and dose exponent were replaced with source-defined compartment parameters. The new curves represent the injected-drug component only, with zero initial drug exposure unless earlier doses are supplied. They do not add or predict endogenous testosterone, and total-testosterone laboratory bands do not apply to them.
Does a smoother model curve establish fewer side effects?
No. Changes in calculated peaks or troughs do not by themselves establish changes in symptoms, estradiol, hematocrit or other clinical outcomes. The model should not be used to choose a treatment schedule.
Educational use only — not medical advice.