Enclomiphene PCT

Five-day timing is a legacy illustration; no single measured half-life for the mixture accepted. The retained 120 h slower timescale is an assumption.

One 1 mg input peaks at 1 relative unit after a single dose. Other amounts scale proportionally; overlapping doses add when accumulation is on. Different compounds use separate relative scales.

Timing half-life used

120 hours

Absorption half-life assumed

30 hours

Reference amount for the relative scale

1 mg

• Absorption half-life is assumed to be one quarter of the slower timescale (30 h); it is not a measured absorption parameter.
• A single 1-unit input has a peak of 1 relative unit; scaling and repeated-dose addition are mathematical assumptions. This normalization is independent of the example dose.
• Two separate 15 ng/mL peaks at different times are not a 30 ng/mL mixture Cmax.
• Do not model enclomiphene alone as Clomid.

• Ghobadi et al 2009: clomiphene isomers in PCOS

  50 mg citrate:Zu peak 15 ng/mL at 7 h, AUC 0–456=1289; En peak 15 at 3 h, AUC 0–72=65; reliable terminal model parameters could not be obtained.

• Mikkelson 1986: clomiphene in volunteers

  24 healthy women;50 mg; isomer concentrations and persistence differ.

• Clomiphene citrate label

  Product is 30–50% cis isomer and 50 mgcitrate; cis persists much longer.

clomid-relative-timing-2026-10 · version 1