Standard PCT: Nolvadex + Clomid (4 weeks)

Label terminal 120–168 h;144 h midpoint is a timing assumption.

One 1 mg input peaks at 1 relative unit after a single dose. Other amounts scale proportionally; overlapping doses add when accumulation is on. Different compounds use separate relative scales.

Timing half-life used

144 hours

Absorption half-life assumed

0.6364052 hours

Reference amount for the relative scale

1 mg

• The faster rate is inferred to match the 5 h source-scoped peak time; absorption half-life 0.6364052012164843 h is a mathematical shape parameter, not separately measured.
• A single 1-unit input has a peak of 1 relative unit; scaling and repeated-dose addition are mathematical assumptions. This normalization is independent of the example dose.
• One-compartment predicts steady mean 354.7 ng/mL (~2.91×122); biphasic parent kinetics and metabolites require more than aterminal exponential.
• Do not sum parent+N-desmethyl/endoxifen as equal drug action.
• Tablet dose is tamoxifen base equivalent, not mass of citrate salt.

• Tamoxifen citrate prescribing information

  20 mg single dose parentpeak 40 ng/mL at 5 h; terminal 5–7 days;20 mg/day chronic meanparent 122 ng/mL; N-desmethyl 353 ng/mL.

nolvadex-relative-timing-2026-10 · version 1

Five-day timing is a legacy illustration; no single measured half-life for the mixture accepted. The retained 120 h slower timescale is an assumption.

One 1 mg input peaks at 1 relative unit after a single dose. Other amounts scale proportionally; overlapping doses add when accumulation is on. Different compounds use separate relative scales.

Timing half-life used

120 hours

Absorption half-life assumed

30 hours

Reference amount for the relative scale

1 mg

• Absorption half-life is assumed to be one quarter of the slower timescale (30 h); it is not a measured absorption parameter.
• A single 1-unit input has a peak of 1 relative unit; scaling and repeated-dose addition are mathematical assumptions. This normalization is independent of the example dose.
• Two separate 15 ng/mL peaks at different times are not a 30 ng/mL mixture Cmax.
• Do not model enclomiphene alone as Clomid.

• Ghobadi et al 2009: clomiphene isomers in PCOS

  50 mg citrate:Zu peak 15 ng/mL at 7 h, AUC 0–456=1289; En peak 15 at 3 h, AUC 0–72=65; reliable terminal model parameters could not be obtained.

• Mikkelson 1986: clomiphene in volunteers

  24 healthy women;50 mg; isomer concentrations and persistence differ.

• Clomiphene citrate label

  Product is 30–50% cis isomer and 50 mgcitrate; cis persists much longer.

clomid-relative-timing-2026-10 · version 1